Cell state · L2
NEU.INH_VIP.canonical_disinhibitory
552 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
GALNT17, NELL1, NELL2, PCDH19, PROS1, PTH2R, RGS6, VIP
Annotation genes
NELL1, NELL2, PCDH19, VIP
Annotation rationales
VIP establishes identity; adhesion PCDH19 and organizers NELL1/NELL2 position synapses on SST/PV cells. PTH2R/PROS1 add neuromodulatory and immune–vascular crosstalk.
Functional implications
Suppresses dendrite-targeting SST and soma-targeting PV interneurons to lift inhibition on pyramidal dendrites, enhancing plasticity and top–down modulation during learning and attention.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.