Cell state · L2
NEU.INH_VIP.cannabinoid
157 cells in the full atlas (not the displayed sample).
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Marker genes
CNR1, GABRG1, PCLO, PDLIM5, RUNX2, RXFP1, SLC17A8
Annotation genes
CNR1, PCLO, SLC17A8
Annotation rationales
Endocannabinoid sensitivity (CNR1) allows rapid suppression of inhibitory drive; SLC17A8 (VGLUT3) enables glutamate co-release; PCLO scaffolds active zones for high vesicle throughput.
Functional implications
Implements state-dependent disinhibition: endocannabinoids reduce VIP activity to let SST/PV inhibition dominate or, via VGLUT3 co-release, deliver excitatory drive to interneuron targets—supporting exploration, reward learning, and gating of sensory flow.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.