Cell state · L2
NEU.INH_PVALB.chandelier
512 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
ADGRG6, BCL11A, DMD, EDNRA, EPB41L2, FAM89A, GRIK1, KLF5, MAN1A1, MCUB, NELL1, NMU, PDE1A, POU3F3, PTPRR, RCAN3, RELN, RGS6, ROBO2
Annotation genes
GRIK1, RELN, ROBO2
Annotation rationales
RELN and ROBO2 guide axo-axonic targeting to the AIS, while GRIK1 allows glutamatergic modulation of firing. Adhesion/structural genes support precise synaptic placement on initial segments.
Functional implications
Exerts powerful, time-locked inhibition of the AIS to gate spike initiation, aligning pyramidal output with circuit rhythms and reducing epileptiform discharges.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.