Cell state · L2
NEU.EXC_IT.neuromodulated
979 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
Read trait, study and gene evidence reports for this population →
Explore this population in Cell Browser →
Marker genes
BCAM, CD163L1, CLMP, COBLL1, GNG4, KCNH5, MME, MYLK, NGB, NPFFR2, PKP1, PLCH1, ITGA11, SLC38A11, TSHZ2, VWC2L
Annotation genes
GNG4, KCNH5, NGB, NPFFR2, TSHZ2
Annotation rationales
GNG4/PLCH1 denote robust GPCR coupling and phosphoinositide signaling; NPFFR2 confers sensitivity to neuropeptide FF; KCNH5 sets repolarization kinetics; NGB buffers O₂/ROS in metabolically taxed neurons; TSHZ2 specifies IT sublineage.
Functional implications
Implements state-dependent gain control: neuromodulators adjust membrane kinetics (KCNH5) and spike thresholds via GNG4/NPFFR2, while NGB preserves fidelity under sustained activity—supporting attentional shifts and behavioral flexibility.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.