Cell state · L2
NEU.EXC_IT.adhesion
1,339 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
Read trait, study and gene evidence reports for this population →
Explore this population in Cell Browser →
Marker genes
CCK, CDH12, CDH13, CNTN4, CTNNA2, GRIK3, IGSF21, LRP1B, NFIA, NPTX1, PEG10, SOX5
Annotation genes
CCK, CDH13, CNTN4, CTNNA2, NPTX1
Annotation rationales
Local and callosal connectivity are scaffolded by CTNNA2, CNTN4, and CDH13, while NPTX1 stabilizes excitatory synapses. CCK modulates presynaptic release probability and interneuron recruitment. SOX5/NFIA maintain IT layer identity.
Functional implications
Builds dense associative microcircuits with adjustable short-term plasticity. Adhesion molecules (CDH13/CNTN4/CTNNA2) set synapse positions and strengths; NPTX1 consolidates connections; CCK shapes presynaptic gain—facilitating working memory and flexible routing across cortical areas.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.