Cell state · L2
NEU.EXC_CT.remodeling
464 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
B2M, CADM1, COLCA1, ELAVL2, EPB41L4A, FGFR1, GALNT13, HLA-A, HLA-C, IGFBP5, KCNIP1, MGAT4C, PTN, PTPRT, SEZ6, SPHKAP, UNC13C, UTRN, VCAN
Annotation genes
FGFR1, HLA-A, KCNIP1, PTN, PTPRT, SEZ6, SPHKAP, UNC13C, UTRN, VCAN
Annotation rationales
Structural plasticity is supported by ECM/scaffold genes VCAN, UTRN, and SEZ6, while the PTN–FGFR1 axis drives neurite extension and synapse maturation. PTPRT regulates presynaptic dephosphorylation; UNC13C primes vesicle release; KCNIP1 modulates A-type K⁺ channels to affect firing onset. HLA-I (HLA-A) signals experience-dependent synapse refinement. SPHKAP links sphingolipid signaling to microdomain organization.
Functional implications
Dynamically reshapes axons and terminals to recalibrate corticothalamic connectivity. ECM remodeling (VCAN/UTRN/SEZ6) and PTN/FGFR1 growth signals promote rewiring, while PTPRT/UNC13C/KCNIP1 retune release probability and excitability—supporting developmental maturation, skill learning, and recovery after perturbation.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.