Cell state · L2
NEU.EXC_CT.projector
823 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
ADGRL2, CADPS2, CPLX2, CREG2, EPB41L3, EPHA4, GABRA3, GNAL, HLF, HOPX, KCNA1, KCNQ5, LDB2, LSAMP, NCALD, NECAB1, PCDH10, PCDH7, PEX5L, PPP1R1A, RSPO2, RSPO3, SCN1A, SEMA5A, SORCS1, SORL1, SPOCK1, SYNDIG1, TCF4, WLS
Annotation genes
CADPS2, EPHA4, GNAL, KCNA1, KCNQ5, PCDH7, RSPO2, SCN1A, SEMA5A, WLS
Annotation rationales
Long-range projection fidelity is reinforced by Wnt/RSPO axis genes WLS and RSPO2, with axon-guidance via EPHA4, SEMA5A, and PCDH7. High-output synaptic machinery (CADPS2, CPLX2) and spike-shaping channels (SCN1A, KCNA1, KCNQ5) support sustained, state-tunable firing. GNAL integrates neuromodulatory GPCR signals to adjust cAMP levels and excitability.
Functional implications
Provides robust, precisely targeted corticothalamic output. Wnt/RSPO-dependent axon maintenance (WLS/RSPO2) and guidance (EPHA4/SEMA5A/PCDH7) ensure accurate thalamic targeting, while ion-channel composition (SCN1A/KCNA1/KCNQ5) stabilizes spike trains across behavioral states, supporting attention, arousal transitions, and predictive coding.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.