Cell state · L2
NEU.EXC_CT.Ca2_signaling
349 cells in the full atlas (not the displayed sample).
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Marker genes
CDH12, CEP126, CTNNAL1, GALNTL6, ITPR2, LINC02223, LINGO2, LRMDA, PLCE1, PPFIBP1, RASSF4, TIA1, TTC29, ZNF286A
Annotation genes
CEP126, CTNNAL1, ITPR2, LINGO2, PLCE1, PPFIBP1, TIA1
Annotation rationales
ITPR2 and PLCE1 promote ER-derived Ca²⁺ release and PLC signaling that shape backpropagating dendritic spikes; PPFIBP1 organizes presynaptic active zones and vesicle docking. CEP126 (centrosome), CTNNAL1, and LINGO2 align cytoskeletal/adhesion cues with axon transport and myelination status. TIA1 couples activity to local translational control, ensuring synaptic proteins are produced on demand.
Functional implications
Precisely modulates dendritic excitability via ER Ca²⁺ waves (ITPR2/PLCE1) and aligns vesicle positioning (PPFIBP1) with axonal delivery (CEP126/CTNNAL1). Enables CT neurons to adapt their output and conduction reliability as circuit demands change (e.g., attention or sleep), coordinating local translation (TIA1) with wiring maintenance (LINGO2).
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.