Cell state · L2
MONO.CD14.inflammatory
684 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
BIRC3, CCL20, CXCL1, CXCL3, CXCL4L2, GJB2, IL1A, IL1B, IL23A, SOD2, TNFAIP6
Annotation genes
CCL20, CXCL1, IL1A, IL1B, IL23A
Annotation rationales
IL1A/IL1B/IL23A drive potent IL-1/Th17-biased inflammation; CXCL1/3 recruit neutrophils; mitochondrial SOD2 supports ROS-rich environments; BIRC3 protects from apoptosis.
Functional implications
Act as cytokine/chemokine engines to mobilize granulocytes and promote antibacterial Th17 responses, forming the acute inflammatory spearhead.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.