Cell state · L2
MESO.secretory_structural
183 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
Read trait, study and gene evidence reports for this population →
Explore this population in Cell Browser →
Marker genes
CLU, HP, ITLN1, SERPING1, UPK3B
Annotation genes
CLU, ITLN1, SERPING1, UPK3B
Annotation rationales
Secretory chaperone CLU stabilizes extracellular proteins and limits complement-mediated bystander damage; SERPING1 (C1-INH) directly restrains classical complement, crucial at fluid-facing serosa; HP binds free hemoglobin reducing oxidative injury; ITLN1 (omentin-1) modulates insulin signaling and immune tone in visceral fat; UPK3B supports apical membrane structure for barrier function. Together these define a mesothelium that conditions pericardial/omental fluids and protects underlying tissues.
Functional implications
Heart: secrete complement regulators (SERPING1, CLU) into pericardial fluid to suppress sterile inflammation and adhesion formation; HP scavenges heme after microbleeds, preserving epicardial cells and coronary endothelium. Adipose: release ITLN1/CLU to improve local insulin sensitivity and temper macrophage activation; reinforce the serosal surface (UPK3B) to withstand mechanical stress from feeding/respiration cycles.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.