Cell state · L2
MEL.mature_oxidative_traffic
1,232 cells in the full atlas (not the displayed sample).
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Marker genes
CALR, CAPG, COX7B, FEZ1, RAB32, S100A1, SLC25A4, SYNGR1
Annotation genes
COX7B, RAB32, SLC25A4
Annotation rationales
Fully differentiated epidermal melanocytes require ATP and specialized trafficking to build/ship melanosomes. COX7B (mitochondrial complex IV) and SLC25A4/ANT1 (ADP/ATP carrier) denote high oxidative phosphorylation to fuel tyrosinase activity and vesicle dynamics. RAB32 controls melanosome biogenesis and cargo sorting toward dendrites for transfer to keratinocytes. Support genes (CALR, S100A1) facilitate Ca²⁺ homeostasis that gates TYR/TYRP activity and exocytic events.
Functional implications
Sustain high-throughput melanogenesis and precise melanosome trafficking to suprabasal keratinocytes, thereby forming an effective UV-absorbing umbrella over nuclei; maintain mitochondrial output (COX7B, SLC25A4) to power biosynthesis and dendritic transport; use RAB32 to ensure correct melanosome maturation, positioning, and hand-off for uniform skin photoprotection.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.