Cell state · L2

HPC.MPP_activated

227 cells in the full atlas (not the displayed sample).

These are the cell-population annotations shown in the SCREATE Cell Browser.

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Marker genes

BTG2, C11orf96, C6orf62, CROCC, EGR1, KCNQ10T1, LINC00910, PPP1R10, RHOB, SDCBP2, SLC9A1, SNAI1, SOCS1, TSPYL2, TUBB4B, WDR74

Annotation genes

BTG2, EGR1, SOCS1

Annotation rationales

EGR1 marks cytokine-driven exit from dormancy; BTG2 enforces controlled proliferation to avoid exhaustion; SOCS1 provides negative feedback to JAK/STAT signaling, preventing runaway activation. Cytoskeletal/adhesion changes (e.g., RHOB, SNAI1) accompany mobilization from the niche, typical of multipotent progenitors (MPPs) entering active cycling.

Functional implications

Rapidly amplify lineage-committed progenitors on demand, coupling controlled proliferation (BTG2) with cytokine responsiveness and self-limiting brakes (SOCS1). Bridge HSC/LMPP pools to downstream CMP/CLP outputs during stress hematopoiesis.

Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.