Cell state · L2
HPC.MPP_IEG
563 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
AVP, BEX1, CDH7, CLEC14A, CLEC3B, HES1, HSD17B14, IDS, KLF4, LMNA, MLF1, NR4A2, PTGS2, RASSF6, RILPL2, SELENOM, SGIP1, TCEAL2, ZNF331
Annotation genes
HES1, KLF4, NR4A2, PTGS2
Annotation rationales
KLF4, NR4A2, and HES1 compose an immediate-early TF network that rapidly reprograms gene expression upon cytokine or stress sensing; PTGS2 (COX-2) integrates inflammatory lipid mediators with proliferative cues. This IEG-rich state typifies plastic MPPs oscillating between quiescence and commitment, enabling swift lineage biasing when demand spikes.
Functional implications
Serve as a flexible “shock-absorber” pool: rapidly interpret inflammatory/stromal cues (PTGS2) and pivot differentiation trajectories via IEG TFs (KLF4/NR4A2/HES1). Supply whichever downstream myeloid or lymphoid progenitors are acutely needed, stabilizing overall hematopoietic output.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.