Cell state · L2
HPC.MEP
916 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
Read trait, study and gene evidence reports for this population →
Explore this population in Cell Browser →
Marker genes
BMP2K, CNRIP1, CTNNBL1, CYTOR, FBXO7, FCER1A, GATA1, GATA2, ICAM4, MINPP1, MPP1, NAA38, PDLIM1, PKIG, PRKAR2B, PSTPIP2, SLC40A1, SMIM1, SNX5, TFR2
Annotation genes
GATA1, GATA2, ICAM4, SMIM1, TFR2
Annotation rationales
GATA1/GATA2 orchestrate erythroid/megakaryocytic fate; ICAM4 (LW blood group) and SMIM1 (Vel antigen) are erythroid surface markers; TFR2 integrates iron availability with erythropoiesis. Presence of platelet/megakaryocyte-affiliated modules with red-cell antigens defines a classical MEP engaged in heme synthesis, enucleation programs, and thrombopoiesis.
Functional implications
Produce erythrocytes and platelets in proportion to iron and growth-factor cues (TFR2, GATA1/2). Elevate oxygen-carrying capacity and hemostatic readiness in rapidly growing neonates; tune red-cell membrane maturation (ICAM4/SMIM1) en route to reticulocyte release.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.