Cell state · L2
HPC.LMPP
909 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
ANGPT1, CD48, GIMAP7, GNG11, HLF, HOPX, IFITM1, IPO11, LINC01819, LRRC70, MFAP4, NKAIN2, NOG, NPAS3, RCSD1
Annotation genes
ANGPT1, HLF, HOPX, IFITM1, RCSD1
Annotation rationales
HLF and HOPX mark quiescent, self-renewing hematopoietic progenitors; ANGPT1 signaling aligns with a niche-interacting, stem-leaning state resistant to stress; RCSD1 (CapZIP) and GIMAP7 support lymphoid skew; IFITM1 denotes interferon-primed readiness typical of neonatal hematopoiesis. These features define lymphoid-primed multipotent progenitors (LMPPs) with residual myeloid potential.
Functional implications
Act as a reservoir for adaptive lineages, preferentially producing T, B, and NK cells while retaining emergency myelopoiesis. Maintain quiescence-to-activation balance (HLF/HOPX/ANGPT1) and rapid IFN-tuned responsiveness (IFITM1) to seed early lymphoid compartments.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.