Cell state · L2
HPC.GMP_inflammatory
746 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
ANXA1, CD9, CRIP1, CRIP2, CXCL8, EMP1, FHL1, GBP2, GSN, ID1, ID2, ID3, LAG3, MAMDC2, PTMS, S100A10
Annotation genes
ANXA1, CXCL8, ID2, ID3, S100A10
Annotation rationales
CXCL8 (IL-8) production flags an autocrine/paracrine granulopoietic accelerator; ANXA1 and S100A10 couple membrane repair with plasminogen/tPA docking to facilitate migration and degranulation; ID2/ID3 tune E-protein activity to bias myeloid/DC differentiation while restraining lymphoid programs. This constellation typifies GMPs primed by inflammatory cytokines to accelerate myeloid output and emergency granulopoiesis.
Functional implications
Supply “emergency” neutrophils/monocytes and inflammatory DCs by leveraging ID2/ID3-directed myeloid bias and chemokine self-stimulation (CXCL8). Enable swift recruitment and effector maturation, with ANXA1/S100A10 supporting motility and degranulation during acute inflammatory demand.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.