Cell state · L2
HPC.CLP_B_primed
167 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
ACY3, BLNK, CCR7, CCR9, CD7, CD79A, CNTNAP2, DNTT, IFNG-AS1, IRF8, JCHAIN, KIAA0087, LGMN, LINC00865, LSAMP, LTB, MME, NPTX2, PACSIN1, SPON1
Annotation genes
BLNK, CD79A, DNTT, IRF8, JCHAIN
Annotation rationales
BLNK and CD79A encode core BCR adaptor and signaling subunits, wiring pre-BCR responsiveness; DNTT (TdT) marks active V(D)J diversification at the pro/pre-B stage; IRF8 supports early B/DC fate choice and reinforces B-lineage gene programs; JCHAIN indicates early commitment toward antibody-secreting trajectories (IgA/IgM polymerization). Co-expression of homing cues (CCR7/CCR9) and MME (CD10) is consistent with common lymphoid progenitors (CLPs) transitioning to B-biased precursors.
Functional implications
Seed the B lineage by executing recombination (DNTT) and assembling pre-BCR signaling (BLNK/CD79A), while maintaining B/DC competency (IRF8). Deliver waves of naïve B cells and early plasmablasts (JCHAIN) to establish humoral immunity and diversify the infant B-cell repertoire.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.