Cell subtype · L1S
HEP.periportal_metabolic
18,917 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
CPS1, ASS1, PCK1, HAL, ALB
Annotation genes
CPS1, PCK1, HAL
Annotation rationales
Periportal metabolic hepatocytes occupy the oxygen-rich portal zone and emphasize gluconeogenesis, amino-acid catabolism and the urea cycle.
Functional implications
They maintain blood glucose and nitrogen balance and perform oxidative metabolic tasks favored by portal nutrient and oxygen supply.
More specific populations
- HEP.periportal_metabolic.acute_phase_barrier
- HEP.periportal_metabolic.apolipoprotein_secretory
- HEP.periportal_metabolic.canonical_urea_cycle
- HEP.periportal_metabolic.inflammatory_activated
- HEP.periportal_metabolic.stress_chaperone
- HEP.periportal_metabolic.stress_checkpoint
- HEP.periportal_metabolic.urea_onecarbon_secretory
- HEP.periportal_metabolic.xenobiotic_detox
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.