Cell state · L2
HEP.acute_phase.stress_secretory
530 cells in the full atlas (not the displayed sample).
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Marker genes
ALB, APOA1, APOC3, APOE, MT-ATP6, MT-ATP8, MT-CO1, MT-CO2, MT-CYB, MT-ND1, MT-ND3, MT-ND5, RBP4, TTR
Annotation genes
ALB, APOA1, APOE, MT-ATP6, MT-CO1, MT-ND1, TTR
Annotation rationales
High mitochondrial gene load (MT-CO1, MT-ND1, MT-ATP6) supports energy-intensive secretion of major serum proteins (ALB, TTR) and apolipoproteins (APOA1, APOE). This indicates hepatocytes that upshift oxidative phosphorylation to sustain secretory throughput under stress.
Functional implications
Maintains systemic transport (albumin, TTR) and lipid carriage (APOA1/APOE) during stress by boosting mitochondrial ATP production; stabilizes plasma oncotic pressure and lipoprotein flux.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.