Cell state · L2
HEP.acute_phase.proliferative
256 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
CENPM, CENPU, CLSPN, DTL, E2F7, E2F8, EXO1, FAM111B, FANCI, HELLS, KIF24, MCM10, NCAPG, NUSAP1, PRC1, RIBC2, TCF19, UHRF1, WDR76
Annotation genes
E2F7, E2F8, HELLS, MCM10, PRC1, UHRF1
Annotation rationales
E2F7/E2F8 activation with replication factors (MCM10, CLSPN) and chromatin regulators (HELLS, UHRF1) marks cell-cycle entry typical of regenerative responses after toxic/inflammatory loss. This is a proliferative hepatocyte state rebuilding parenchymal mass.
Functional implications
Drives hepatocyte replication and chromatin re-establishment to restore liver mass and function after injury, ensuring continuity of metabolic and synthetic output.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.