Cell state · L2
HEP.acute_phase.inflammatory
1,653 cells in the full atlas (not the displayed sample).
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Marker genes
CCL20, CLIC4, CXCL1, CXCL3, CXCL8, FCAMR, FTH1, ICAM1, IRF1, MAP3K8, NFKB1, NFKB2, NFKBIA, RND1, TNFAIP2, TNFAIP3, TNIP1, UBD
Annotation genes
CCL20, CXCL1, CXCL3, CXCL8, NFKB1, NFKB2
Annotation rationales
A classic NF-κB-driven chemokine burst: NFKB1/NFKB2 with NFKBIA/TNFAIP3 feedback, and neutrophil-recruiting CXCL1/CXCL3/CXCL8 plus CCL20 for CCR6⁺ cells. ICAM1 facilitates leukocyte adhesion in sinusoids. This designates hepatocytes as active coordinators of hepatic inflammation and neutrophil trafficking.
Functional implications
Orchestrates leukocyte recruitment to the liver by secreting CXCL1/3/8 and CCL20 and presenting ICAM1; shapes the magnitude/duration of inflammation via NFKB1/2 programs and their brakes.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.