Cell state · L2
HEP.acute_phase.hypoxia_lipid
100 cells in the full atlas (not the displayed sample).
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Marker genes
AHSG, AQP3, EFNA1, ERO1A, GSTM2, HILPDA, NDRG1, RAP2B
Annotation genes
AHSG, AQP3, GSTM2, HILPDA, NDRG1
Annotation rationales
Zone-specific or congestive hypoxia triggers NDRG1 and lipid-droplet regulator HILPDA, pointing to oxygen-limited FA storage and oxylipin tuning. AHSG (fetuin-A) is a hepatokine that modulates insulin sensitivity and inflammation, often elevated in steatotic/acute-phase settings. AQP3 supports osmotic/glycerol flux, and GSTM2 provides GSH-dependent detox. Together these genes indicate hepatocytes adapting to low O₂ while buffering lipid and redox stress.
Functional implications
Mitigates hypoxia by shifting toward lipid droplet storage (HILPDA), maintaining redox detox (GSTM2), and adjusting systemic insulin/inflammatory tone via AHSG; AQP3 supports glycerol/solute balance. Protects parenchyma during hypoxic/inflammatory insults.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.