Cell state · L2
HEP.acute_phase.complement_metabolic
4,176 cells in the full atlas (not the displayed sample).
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Marker genes
ADH4, ANGPTL3, C8B, CDO1, CFHR1, CFHR2, DNAJB1, EGLN3, HSD17B13, HSPE1, IGFBP1, LEAP2, MCL1, MPC1, P4HA1, SLC2A2, SPTSSA, TTPA, VNN1, ZFP36L1
Annotation genes
C8B, CFHR1, CFHR2, HSD17B13, IGFBP1, SLC2A2
Annotation rationales
Strong complement tone (C8B, CFHR1/CFHR2) coexists with metabolic re-routing: SLC2A2 (GLUT2) for hepatocyte glucose exchange, HSD17B13 for lipid droplet/retinoid-linked metabolism, and ANGPTL3 (marker in set) for lipoprotein control. IGFBP1 couples hepatocyte nutrient status to endocrine axes. This indicates an acute-phase state that prioritizes host defense while actively reallocating carbohydrate/lipid flux.
Functional implications
Coordinates opsonization/lysis (C8B, CFHR1/2) with regulated glucose uptake/release (SLC2A2) and lipid handling (HSD17B13), broadcasting metabolic status via IGFBP1. Outcome: systemic defense with adaptive energy partitioning during inflammation.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.