Cell state · L2
HEP.acute_phase.complement_antiviral
1,573 cells in the full atlas (not the displayed sample).
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Marker genes
C4A, C4B, CYP3A5, DDX21, DDX24, DST, FTCD, HIPK2, IFITM1, ITPR2, MAN2C1, PARP14, RRBP1, SETD2, SON, SRRM2, STAT2, UPF2
Annotation genes
C4A, C4B, CYP3A5, IFITM1, PARP14, STAT2
Annotation rationales
A coordinated antiviral/innate program couples interferon signaling and complement. STAT2 and PARP14 denote active IFN-JAK/STAT circuitry; IFITM1 restricts viral entry; C4A/C4B amplify complement-mediated opsonization. Concurrent CYP3A5 expression preserves xenobiotic clearance during infection. This profile reflects hepatocytes acting as immune effectors while maintaining core metabolic/biotransformation roles.
Functional implications
Provides hepatotropic antiviral readiness—blocking viral spread (IFITM1), producing complement (C4A/C4B), and sustaining detox (CYP3A5). These cells integrate IFN signals (STAT2, PARP14) to protect liver parenchyma and circulation.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.