Cell state · L2
HEP.acute_phase.baseline
5,139 cells in the full atlas (not the displayed sample).
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Marker genes
AKAP7, C3, CFAP221, CFHR4, CYP2E1, LIPG, MYOM1, NAMPT, ORM1, PLA2G2A, SAA1, SAA2
Annotation genes
C3, CYP2E1, NAMPT, ORM1, SAA1, SAA2
Annotation rationales
Hepatocytes are the principal source of systemic acute-phase proteins. The co-expression of SAA1/SAA2 (serum amyloid A), ORM1 (orosomucoid), and C3 (central complement component) marks a canonical acute-phase secretory baseline. CYP2E1 indicates preserved xenobiotic/ethanol oxidation capacity under homeostatic conditions, while NAMPT links inflammatory signaling to NAD⁺ salvage and cellular stress tolerance. Together these genes indicate a hepatocyte poised to sense cytokines (e.g., IL-1/IL-6), maintain detox programs (CYP2E1), and secrete opsonins (C3) and transport modulators (ORM1, SAA1/2).
Functional implications
Sustains liver-wide readiness for inflammatory cues by supplying foundational opsonins (C3) and acute-phase modulators (SAA1/2, ORM1), while ensuring ongoing drug/ethanol clearance (CYP2E1) and metabolic resilience (NAMPT). Net effect: stable systemic host defense with preserved hepatocyte homeostasis.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.