Cell state · L2
EPI.thymic_medullary.stress_APC
495 cells in the full atlas (not the displayed sample).
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Marker genes
ARG2, ARID5A, BAZ1A, CRIP1, CSRNP1, EFNA1, FOSL1, HLA-E, LDHA, LMNA, MAFF, SERTAD1, SOD2, TRIB1, TRIP10
Annotation genes
ARID5A, HLA-E, LDHA, MAFF, SOD2
Annotation rationales
Under inflammatory/metabolic stress, mTECs switch to glycolysis (LDHA) and boost mitochondrial ROS defense (SOD2) yet sustain antigen display (HLA-E), with ARID5A/MAFF stabilizing immune-gene transcripts and oxidative responses. Chromatin remodelers (BAZ1A) allow rapid reprogramming without losing identity.
Functional implications
Preserves the quality and continuity of antigen presentation during stress, preventing transient tolerance failures. Protects epithelial integrity while allowing cytokine exposure, thereby avoiding autoimmune priming from a disrupted medullary niche.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.