Cell subtype · L1S
EPI.renal_thick_ascending_limb
7,592 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
SLC12A1, UMOD, KCNJ1, CLDN16, CLDN10, FXYD2
Annotation genes
SLC12A1, UMOD, KCNJ1, CLDN16
Annotation rationales
Thick ascending-limb cells are water-impermeable nephron epithelial cells that perform vigorous sodium–potassium–chloride transport. UMOD and SLC12A1 are characteristic of this segment.
Functional implications
They generate the medullary osmotic gradient, dilute tubular fluid and support paracellular calcium and magnesium reabsorption.
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