Cell state · L2
EPI.ileal_enterocyte_absorptive.brush_border
1,626 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
ACADVL, ACSL5, ACTG1, ATF3, CCNL1, CDHR2, CDHR5, CDKN1A, CLDN4, CYP3A5, DDX5, DGAT1, DUSP1, EGR1, ELF3, EPS8L2, EPS8L3, ETS2, EZR, FHL2, FOS, GADD45B, GDA, GK, HKDC1, IFRD1, JUN, KLF6, LDLR, MALAT1, MCL1, MME, MUC13, MXD1, MYO15B, PCK1, PDK4, POR, RIOK3, SGK1, SLC13A2, SLC5A1, SLC6A19, SQSTM1, SRRM2, TMC5, TNFRSF1A, ZFP36
Annotation genes
ACSL5, CDHR2, CDHR5, CYP3A5, DGAT1, EPS8L2, EZR, LDLR, MUC13, PCK1, PDK4, POR, SLC5A1, SLC6A19
Annotation rationales
CDHR2/5, EZR, and EPS8L2/3 assemble and maintain dense microvilli. SLC5A1 (SGLT1) and SLC6A19 (B^0AT1) mediate glucose and neutral amino-acid uptake; ACSL5/DGAT1 re-esterify fatty acids; LDLR handles cholesterol uptake. POR/CYP3A5 provide xenobiotic and bile-metabolite detox; PCK1/PDK4 enable metabolic switching between carbohydrate and fat oxidation; CLDN4/MUC13 sustain barrier at the villus.
Functional implications
Executes high-capacity uptake of sugars, amino acids, and fats with robust microvillar architecture; detoxifies luminal xenobiotics; flexibly adjusts cellular fuel use according to diet; maintains a tight yet absorptive barrier at the villus surface.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.