Cell state · L2
EPI.hepatic_ductular_cholangiocyte.acute_phase_complement
170 cells in the full atlas (not the displayed sample).
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Marker genes
APOA1, APOA2, ASGR1, C3, C4A, C4B, C8G, CFB, CP, FTCD, G0S2, GLDC, ITIH3, ITIH4, MST1, NSUN6, ORM1, SAA1, SAA2
Annotation genes
APOA1, C3, C4A, C4B, C8G, CFB, CP, ITIH3, SAA1
Annotation rationales
High complement (C3/C4/CFB/C8G) and acute-phase proteins (SAA1/2, ORM1, APOA1/2, CP, ITIHs) typify ductular reaction cells that bathe bile with opsonins. ASGR1 underscores hepatobiliary interface features.
Functional implications
Secretes complement and acute-phase factors into bile to opsonize microbes and neutralize endotoxins during cholangitis; supports immune cell recruitment and enhances pathogen clearance while ducts remodel.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.