Cell state · L2
EPI.ectocervical_granular.inflammatory
28 cells in the full atlas (not the displayed sample).
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Marker genes
ACSL1, ANKRD37, CXCL2, CXCL3, DDIT4, HCG20, HILPDA, KLK6, SAMSN1, TNF, VIM
Annotation genes
CXCL2, CXCL3, HILPDA, TNF, VIM
Annotation rationales
TNF and CXCL2/3 denote active inflammatory signaling and neutrophil recruitment; HILPDA supports lipid-droplet accumulation in hypoxia/inflammation; VIM induction reflects epithelial stress with partial EMT-like remodeling; KLK6 indicates altered protease landscape.
Functional implications
Drives local neutrophilic inflammation, reshapes lipid and protease environments, and transiently loosens epithelial architecture to allow leukocyte passage; promotes wound closure programs while risking EMT and barrier weakening if stimuli persist.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.