Cell state · L2
EPI.ectocervical_granular.immune_interact
69 cells in the full atlas (not the displayed sample).
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Marker genes
BPIFB1, CCL20, CCL4, CCL5, CD52, CD55, CEACAM7, GNLY, GZMA, GZMB, HP, IL2RG, IL36G, MNDA, NKG7, RGS1, TFF3
Annotation genes
CCL20, CCL5, GNLY, GZMA, GZMB, NKG7, TFF3
Annotation rationales
Co-expression of epithelial barrier factor TFF3 with cytotoxic granule genes (GNLY, granzymes, NKG7) and chemokines (CCL5/20) indicates intense epithelial–immune contact or doublets; complement regulators (CD55) and IL36G suggest alarmin signaling at the mucosal surface.
Functional implications
Engages immune cells at the ectocervical surface, amplifying chemokine gradients and presenting danger cues to recruit NK/T cells; strengthens the mucus/barrier layer with TFF3 while tolerating direct cytotoxic cell contact during infections or dysbiosis.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.