Cell state · L2
EC.venous.cardiac_structural
779 cells in the full atlas (not the displayed sample).
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Marker genes
ANKRD36, CREBZF, EPB41L2, HIF3A, NPIPB13, NPIPB5, PRICKLE4, PTPN5, STX16, SYNE1, TNNC1, TPO, XIST
Annotation genes
CREBZF, EPB41L2, STX16, SYNE1
Annotation rationales
SYNE1 anchors the nucleus to cytoskeleton (LINC complex) for mechano-transduction; EPB41L2 supports membrane–cytoskeletal stability. STX16 enables vesicle trafficking, and HIF3A tunes responses to fluctuating oxygen in myocardium. This reflects venous ECs adapting to cyclic strain and variable oxygen in the heart.
Functional implications
Mechanics-adapted venous ECs that withstand cyclic stretch and shear gradients in cardiac venules. They maintain vesicular transport, junctional integrity, and oxygen sensing without overt inflammation, ensuring venous return from myocardium while preventing barrier breakdown under repetitive cardiac load.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.