Cell state · L2
EC.lymphatic.baseline
869 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
EPB41L2, KCNIP1, LYVE1, MMRN1, MYH10, PDE2A, PLSCR4, PPFIBP1, RELN, SPTBN1, STON2, TFPI, TIMP2, WFS1
Annotation genes
LYVE1, MMRN1, TFPI
Annotation rationales
LYVE1 (hyaluronan receptor) and MMRN1/TFPI (matrix/hemostatic control) define capillary/initial LEC identity. Structural spectrin/actin adapters (EPB41L2/SPTBN1/MYH10) and endocytosis/scission factors (STON2/PLSCR4) support vesicular flux without activation. PDE2A/KCNIP1 fine-tune cAMP/Ca²⁺ signaling under low shear. Altogether this is a quiescent, uptake-competent LEC state.
Functional implications
Homeostatic fluid collectors that maintain low-pressure, high-compliance lymph uptake from interstitium while enforcing anticoagulant tone (TFPI) and controlled ECM contact (MMRN1). They continuously scavenge HA via LYVE1 to modulate matrix hydration and ensure smooth entry of solutes, antigens, and migratory DCs toward downstream collectors.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.