Cell state · L2
EC.lymphatic.activated
976 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
BTG1, CDKN1A, DNAJB1, FOS, GADD45B, HES1, HSPA1A, JUN, JUNB, NFKBIA, PPP1R15A, RGS16, RHOB, SOCS3, ZFP36
Annotation genes
DNAJB1, FOS, HSPA1A, JUN, NFKBIA, ZFP36
Annotation rationales
IEG/AP-1 (FOS/JUN/JUNB) and NF-κB brake (NFKBIA) indicate minutes–hours acute activation; ZFP36/PPP1R15A/SOCS3 impose anti-inflammatory/translational brakes to prevent runaway signaling. HSPA1A/DNAJB1 mark a chaperone surge that protects junctional and valve proteins during shear/cytokine stress. CDKN1A/BTG1 transiently restrain the cell cycle, a hallmark of endothelial alarm states. Together this is a classic inflammatory gate-opening LEC profile tuned to remain reversible and protective.
Functional implications
Rapid-response LECs that dilate initial lymphatics, upshift antigen and leukocyte trafficking, and transiently loosen cortical actin to increase cell transit while deploying chaperones to preserve barrier and valve leaflet integrity. They integrate chemokine cues with inhibitory feedback (ZFP36/SOCS3) to resolve inflammation and re-establish low-leak, low-pressure lymph flow once danger subsides.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.