Cell state · L2
EC.liver_sinusoidal.stress
429 cells in the full atlas (not the displayed sample).
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Marker genes
BAG3, CLK1, DNAJA1, DNAJB1, DNAJB4, HSPA1A, HSPA1B, HSPA8, HSPB1, HSPD1, HSPE1, HSPE1-MOB4, HSPH1, ID1, ID3, JUN, JUND, TECR, TRA2B, UBB
Annotation genes
DNAJB1, HSPA1A, HSPH1, JUN
Annotation rationales
Broad heat-shock/chaperone induction (HSPA1A/B, HSPH1, DNAJB1) indicates ER and proteotoxic stress buffering. JUN/JUND/ID1-3 suggest transcriptional adaptation and stress-driven proliferation restraint. This program allows LSECs to survive acute inflammatory or metabolic surges.
Functional implications
Stress-buffering protectors: stabilize proteins, limit ER overload, and preserve fenestrated morphology under inflammatory/metabolic insult. They protect sinusoidal patency and filtration, preventing collapse or barrier breakdown during systemic stress (e.g., sepsis, ischemia–reperfusion).
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.