Cell state · L2
EC.liver_sinusoidal.inflammatory
444 cells in the full atlas (not the displayed sample).
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Marker genes
ARAP2, BAZ1A, CCL2, ICAM1, ITGB3, NFKB1, NFKBIA, NRIP1, PTPN1, SOD2, TNFAIP3, VCAM1
Annotation genes
CCL2, ICAM1, NFKBIA, TNFAIP3, VCAM1
Annotation rationales
ICAM1/VCAM1 upregulation provides firm leukocyte adhesion platforms; CCL2 attracts monocytes/macrophages. NFKB1 drives pro-inflammatory signaling, while TNFAIP3 (A20) and NFKBIA add negative feedback to NF-κB activation, preventing uncontrolled damage. SOD2 buffers ROS, maintaining mitochondrial viability during inflammation.
Functional implications
Immune-recruiting endothelial cells: orchestrate monocyte/T cell entry into sinusoids, amplify local inflammation, but simultaneously deploy NF-κB brakes and ROS detox to sustain perfusion. They act as immune gatekeepers, balancing leukocyte recruitment with protection of fragile sinusoidal architecture.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.