Cell state · L2
EC.liver_sinusoidal.hypoxia_metabolic
916 cells in the full atlas (not the displayed sample).
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Marker genes
ABLIM3, ADD3, AGPAT5, ANKRD37, BNIP3, BNIP3L, DDIT4, DIP2C, EGLN1, EGLN3, ENO1, ERO1A, FAM13A, FCN2, FGF23, FGFR1, FKBP1A, FLT1, GALNT18, GAPDH, GUK1, IL33, INPP5D, INSIG2, LONP1, NGLY1, NPAS2, PDE2A, PDE4D, PEAR1, PGK1, PRKCA, RASGRP3, RIOK3, RNMT, SCARB1, SFMBT2, SLC2A3, SNRK, SNX25, TCAF2, TIPARP, TPI1, VEGFA, WSB1, YEATS2, ZNF292
Annotation genes
BNIP3, BNIP3L, DDIT4, EGLN1, FCN2, SCARB1
Annotation rationales
EGLN1/3, BNIP3/BNIP3L, DDIT4 highlight hypoxia-inducible and mitophagy/autophagy pathways, allowing adaptation to O₂ scarcity. NPAS2 adds circadian modulation, tuning sinusoidal responses to feeding–fasting cycles. SCARB1 confers HDL/oxLDL uptake, while FCN2 equips LSECs for innate lectin-mediated pathogen clearance. This profile reflects metabolic flexibility and innate surveillance under fluctuating oxygen tension.
Functional implications
Hypoxia-adaptive scavengers: shift from oxidative phosphorylation to glycolysis, increase lipid uptake and catabolism, and adjust immune surveillance in a circadian manner. They maintain hepatic filtration during hypoxic episodes (e.g., postprandial or ischemic stress) while scavenging modified lipids and microbial products, preserving liver detoxification function.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.