Cell state · L2
EC.capillary.stress
2,762 cells in the full atlas (not the displayed sample).
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Marker genes
DDIT3, EGR1, HSPD1, HSPE1, HSPE1-MOB4, NR4A1
Annotation genes
DDIT3, EGR1, HSPD1, HSPE1, NR4A1
Annotation rationales
UPR/chaperone markers (DDIT3/CHOP, HSPD1/HSPE1) with IEGs (EGR1, NR4A1) denote proteotoxic/oxidative stress from hypoxia–reoxygenation or hemodynamic spikes. Signature lacks full inflammatory modules, fitting a self-protective, transient stress adaptation.
Functional implications
Barrier-preserving stress buffers: reduce protein misfolding, stabilize junctions, and pause proliferation to avoid catastrophic leak while conditions normalize. This preserves microvascular integrity during acute metabolic or shear insults and sets the stage for recovery or targeted angiogenesis.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.