Cell state · L2
EC.capillary.migratory
1,870 cells in the full atlas (not the displayed sample).
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Marker genes
CCDC106, ZNF580, ZNF581
Annotation genes
ZNF580, ZNF581
Annotation rationales
ZNF580 enhances EC migration/proliferation and can upregulate eNOS, improving perfusion; ZNF581/CCDC106 associate with transcriptional and cytoskeletal programs that support motility. Absence of inflammatory markers suggests a developmental/repair motility state rather than danger signaling.
Functional implications
Pro-sprouting movers: execute motility and mild proliferative programs to extend/repair capillary networks, elevating NO tone to promote perfusion. They facilitate re-endothelialization after micro-injury and help remodel microvascular density in response to metabolic demand.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.