Cell state · L2
EC.capillary.baseline
8,186 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
AQP1, CAV1, CDH5, CLDN5, EMCN, ENG, ESAM, FLT1, ICAM2, KDR, KLF2, KLF4, NOS3, PECAM1, PLVAP, RAMP2, ROBO4, VWF
Annotation genes
CDH5, CLDN5, EMCN, ESAM, FLT1, ICAM2, KDR, NOS3, PECAM1, PLVAP, RAMP2
Annotation rationales
Junctional/core identity (CDH5/CLDN5/PECAM1/ESAM) with EMCN/PLVAP (capillary morphology/transport), KDR/FLT1 (VEGF sensing), KLF2/KLF4 (shear homeostasis), NOS3 (basal NO), and ROBO4/RAMP2 (stability/anti-leak). Lack of ISG/angiogenic surges indicates resting, shear-adapted capillary endothelium.
Functional implications
Barrier and exchange custodians: preserve tight yet flexible capillary barrier, sustain basal NO for tone, and support transendothelial transport (water/solutes/albumin vesicles) without inflammatory activation. Provide stable hemostatic surface (VWF/ENG) while maintaining anti-leak, anti-thrombotic balance.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.