Cell state · L2
EC.capillary.angiocrine
4,079 cells in the full atlas (not the displayed sample).
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Marker genes
CLEC3B, CXCL12, GJA4, SRGN
Annotation genes
CXCL12, GJA4
Annotation rationales
CXCL12 is a canonical angiocrine/niche factor that retains CXCR4⁺ hematopoietic, stromal, and immune cells perivascularly; GJA4 (Cx37) strengthens gap-junction coupling within ECs and with mural cells, stabilizing flow signaling. CLEC3B (tetranectin) and SRGN (serglycin) support matrix–protease interactions and storage/release of mediators. Signature denotes paracrine niche maintenance rather than inflammation.
Functional implications
Perivascular niche builders: secrete CXCL12 to organize stem/immune cell positioning, support vascular stability via gap-junction coupling, and modulate local matrix. They maintain quiescent, trophic microenvironments that enable repair, angiogenesis priming, and immune cell education without barrier breakdown.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.