Cell state · L2
EC.capillary.activated
757 cells in the full atlas (not the displayed sample).
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Marker genes
CCL2, CCL8, CTSS, CX3CL1, CXCL10, CXCL11, CXCL9, GBP1, GBP4, HAPLN3, IDO1, IFI30, IL32, ISG20, PLA1A, UBD, VCAM1
Annotation genes
CTSS, CXCL10, CXCL11, CXCL9, GBP1, GBP4, IDO1, IFI30, ISG20, VCAM1
Annotation rationales
Type-I/II IFN–induced chemokines (CXCL9/10/11) recruit CXCR3⁺ T cells; GBP1/4 and ISG20 indicate antiviral effector programs. IDO1 (tryptophan catabolism) and IFI30/CTSS (endolysosomal proteases) point to enhanced antigen processing and local immunoregulation. VCAM1 licenses firm adhesion/diapedesis, while CX3CL1 supports CX3CR1⁺ monocyte/T cell patrolling. Overall, this is a capillary EC antiviral/inflammatory activation module that couples leukocyte recruitment with heightened antigen handling.
Functional implications
Immune gateway mode: amplifies tissue antiviral surveillance, attracts effector/memory T cells and monocytes, and provides firm adhesion for transendothelial migration. IDO1 tempers excessive inflammation while sustaining antigen presentation. Net effect is rapid containment of infection at the capillary bed with controlled permeability to preserve tissue function.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.