Cell state · L2
EC.arterial.mito_contact
1,204 cells in the full atlas (not the displayed sample).
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Marker genes
COX16, SYNJ2BP
Annotation genes
COX16, SYNJ2BP
Annotation rationales
SYNJ2BP stabilizes mitochondria–ER contacts (MAMs), coordinating Ca²⁺/lipid exchange and localized translation; COX16 promotes complex IV assembly, ensuring efficient electron transfer. Together they support high-fidelity mitochondrial respiration tightly coupled to signaling.
Functional implications
Respiration–signaling integrators: optimize ETC flux and Ca²⁺ microdomain communication to keep NO synthesis and redox tone precise in high-demand arterial segments. This buffers oxidative stress and sustains vasodilatory competence and anti-thrombotic endothelial function under pulsatile pressure.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.