Cell state · L2
EC.arterial.inflammatory
1,659 cells in the full atlas (not the displayed sample).
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Marker genes
ADAMTS9, AKAP12, ARID5A, BCL3, CCL2, CD83, CDKN1A, FOSL1, ICAM1, IL6, INSIG1, IRF1, MAFF, NFKBIA, PHLDA1, RCAN1
Annotation genes
CCL2, CDKN1A, ICAM1, IL6, NFKBIA, RCAN1
Annotation rationales
ICAM1 enables firm leukocyte adhesion; CCL2/IL6 drive monocyte recruitment and paracrine inflammation; NFKBIA and BCL3 provide NF-κB feedback brakes; RCAN1 dampens calcineurin–NFAT signaling; CDKN1A imposes cell-cycle arrest during stress. Profile typifies acute endothelial activation with built-in negative controls.
Functional implications
Inflammation coordinators: open the endothelium for leukocyte rolling/adhesion/diapedesis, release cytokines, then apply feedback brakes to restore quiescence and limit barrier damage. They choreograph immune cell trafficking during infection or injury while protecting the arterial wall from runaway inflammation.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.