Cell state · L2
EC.arterial.homeostatic
2,815 cells in the full atlas (not the displayed sample).
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Marker genes
ADAMTS6, ALPL, AMD1, CLIC3, FUT8, GLUL, NEBL, NTRK2, PI16, PLS3, PODXL, SGK1, SLC12A2, SLC6A6, VEGFA
Annotation genes
GLUL, NTRK2, SGK1, SLC12A2, VEGFA
Annotation rationales
GLUL (glutamine synthetase) buffers nitrogen and supports endothelial metabolism; SGK1–SLC12A2 (NKCC1) manage ion/osmotic balance and shear adaptation; NTRK2 (TrkB) points to neurovascular trophic crosstalk; VEGFA autocrine output sustains arterial integrity. Absence of activation markers indicates tonic, steady-state maintenance.
Functional implications
Set-point keepers: uphold ionic/osmotic homeostasis, maintain anti-leak, anti-inflammatory tone, and sustain perivascular nerve interactions. Autocrine VEGFA preserves junctions and arterial identity during routine shear, supporting long-lived arterial health.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.