Cell state · L2
CM.sarcomere_actin_interface
5,445 cells in the full atlas (not the displayed sample).
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Marker genes
RFLNA, ZNF664
Annotation genes
RFLNA, ZNF664
Annotation rationales
RFLNA (Refilin-A/FAM101A) crosslinks actin–filamin networks, reinforcing costameres and Z-disc connectivity; ZNF664 likely modulates transcriptional responses to structural strain. Absence of stress/hypertrophy modules points to a structural-tuning state rather than injury.
Functional implications
Micro-architecture maintainers that refine actin anchoring and force transmission from sarcomere to membrane/extracellular matrix. They prevent micro-tears under cyclic strain, preserve conduction–contraction alignment, and reduce energy waste by stabilizing myofibrillar registry.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.