Cell state · L2
CM.oxidative_phospho
3,642 cells in the full atlas (not the displayed sample).
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Marker genes
NDUFC2, NDUFC2-KCTD14
Annotation genes
NDUFC2
Annotation rationales
NDUFC2 encodes a Complex I subunit essential for NADH oxidation and proton pumping. Enrichment suggests biased ETC throughput even without a full OXPHOS transcript surge, implying region-specific metabolic specialization (e.g., subendocardial, high-workload sectors).
Functional implications
Complex-I-forward ATP suppliers optimized for high redox flux and efficient oxidative phosphorylation. They stabilize endurance output and support rapid recovery after systole; however, their reliance on Complex I makes them ischemia-vulnerable, prioritizing perfusion coupling in workload-intense zones.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.