Cell state · L2
CM.osmoprotection
1,792 cells in the full atlas (not the displayed sample).
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Marker genes
MRPS6, SLC5A3
Annotation genes
MRPS6, SLC5A3
Annotation rationales
SLC5A3 (SMIT1) imports myo-inositol for phosphoinositide synthesis and osmolyte balance; MRPS6 contributes to mitochondrial small-ribosome function, often co-induced when stress elevates translational demand. Signature fits hypertonicity/hyperglycemia adaptation seen in metabolic stress.
Functional implications
Osmolyte-equipped cardiomyocytes that maintain cell volume and membrane signaling fidelity (PIP₂/PIP₃ pathways) in osmotic/metabolic stress (e.g., diabetes, ischemia–reperfusion). By supporting mito-translation, they keep oxidative capacity aligned with demand, preserving contractile stability.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.