Cell state · L2
CM.mito_proteostasis
4,469 cells in the full atlas (not the displayed sample).
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Marker genes
DNAJC25, DNAJC25-GNG10, FASTKD5, UBOX5
Annotation genes
DNAJC25, DNAJC25-GNG10, FASTKD5, UBOX5
Annotation rationales
FASTKD5 supports mitochondrial RNA maturation/translation; DNAJC25 (Hsp40-like) aids folding/import; UBOX5 is a ubiquitin ligase promoting mito-proteostasis. Enrichment of these without broad stress genes implies a quality-control-skewed mitochondrial program rather than generalized injury.
Functional implications
Mitochondrial upkeep specialists that safeguard ETC assembly and turnover, preventing accumulation of defective complexes during high workload. They blunt ROS-driven dysfunction, sustain ATP output under tachycardia, and reduce triggers for mitochondria-mediated cell death—thereby stabilizing contractile performance.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.