Cell state · L2
CM.mechano_activated
1,682 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
ABRA, ADAMTS1, ANKRD1, ATF3, BTG2, FOS, LMOD2, MYL12A, NR4A1, NR4A3
Annotation genes
ABRA, ANKRD1, ATF3, BTG2, FOS, LMOD2, NR4A1, NR4A3
Annotation rationales
IEGs (FOS/ATF3/NR4A1/NR4A3/BTG2) are classic stretch/β-adrenergic responders. ABRA (STARS) couples actin dynamics to SRF signaling; ANKRD1 is a titin-based mechanosensor linked to Z-disc/N2B tension; LMOD2/MYL12A influence thin-filament assembly and contractile alignment. Together they mark acute mechanotransduction and early remodeling.
Functional implications
Stretch sentinels that translate load and wall stress into gene programs for hypertrophic growth, sarcomere realignment, and protection (e.g., chaperones/anti-apoptosis). They initiate rapid geometry/filament adjustments to preserve ejection fraction during hemodynamic shifts (hypertension, valve disease, intense exercise).
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.